Shalu Jain
Maharaja Agrasen Himalayan Garhwal University
Pauri Garhwal, Uttarakhand, India
Abstract
Rare diseases, often neglected due to limited commercial incentives, pose significant challenges in drug development. This manuscript explores the application of artificial intelligence (AI) to drug repurposing as a cost-effective solution for these conditions. By leveraging machine learning, network analysis, and in silico simulations, AI can accelerate the identification of novel therapeutic uses for existing drugs. This review synthesizes literature up to 2018, outlines a statistical analysis of drug repurposing case studies, and presents a methodological framework integrating AI tools. Our findings suggest that AI-driven approaches not only reduce time and cost in the discovery process but also enhance the likelihood of clinical success for rare diseases, offering promising avenues for future research and healthcare policy.
Keywords
Artificial Intelligence, Drug Repurposing, Rare Diseases, Machine Learning, In Silico Analysis, Cost-Effectiveness, Computational Biology
References
- https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.intechopen.com%2Fchapters%2F72744&psig=AOvVaw1UvbSoq3UVKvmMWJduYY78&ust=1740639753617000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCPjd2c3i4IsDFQAAAAAdAAAAABAN
- https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.mdpi.com%2F1420-3049%2F28%2F7%2F3271&psig=AOvVaw2iigFHxGLFZkSGZyG-xdGe&ust=1740640074161000&source=images&cd=vfe&opi=89978449&ved=0CBQQjRxqFwoTCMCS293j4IsDFQAAAAAdAAAAABAQ
- Ashburn, T. T., & Thor, K. B. (2004). Drug repositioning: identifying and developing new uses for existing drugs. Nature Reviews Drug Discovery, 3(8), 673–683.
- Chong, C. R., & Sullivan, D. J., Jr. (2007). New uses for old drugs. Nature, 448(7154), 645–646.
- Gottlieb, A., Stein, G. Y., Ruppin, E., Sharan, R., & Mitra, R. (2011). PREDICT: a method for inferring novel drug indications with application to personalized medicine. Molecular Systems Biology, 7, 496.
- Overington, J. P., Al-Lazikani, B., & Hopkins, A. L. (2006). How many drug targets are there? Nature Reviews Drug Discovery, 5(12), 993–996.
- Pushpakom, S., Iorio, F., Eyers, P. A., Escott, K. J., Hopper, S., Wells, A., … & Pirmohamed, M. (2018). Drug repurposing: progress, challenges and recommendations. Nature Reviews Drug Discovery, 18(1), 41–58.
- Chen, H., Engkvist, O., Wang, Y., Olivecrona, M., & Blaschke, T. (2018). The rise of deep learning in drug discovery. Drug Discovery Today, 23(6), 1241–1250.
- Lavecchia, A. (2015). Machine-learning approaches in drug discovery: methods and applications. Drug Discovery Today, 20(3), 318–331.
- Li, J., Zheng, S., Chen, B., Butte, A. J., Swamidass, S. J., & Lu, Z. (2016). A survey of current trends in computational drug repositioning. Briefings in Bioinformatics, 17(1), 2–12.
- Li, J., Zheng, S., Chen, B., Butte, A. J., & Swamidass, S. J. (2014). A network-based approach to drug repositioning. Bioinformatics, 30(10), 1449–1456.
- Martínez, J. P., Barreiro-Iglesias, A., & Merino, G. (2013). Computational drug repositioning: a review of the methodologies and applications. Current Topics in Medicinal Chemistry, 13(12), 1445–1456.
- Oprea, T. I., Taboureau, O., Bologa, C., & Southan, C. (2011). Molecular libraries and drug repurposing: advancing high-throughput screening. Journal of Biomolecular Screening, 16(6), 699–704.
- Ekins, S., Puhl, A. C., Zorn, K. M., Lane, T. R., Russo, D. P., Klein, J. J., & Hickey, A. J. (2007). Exploiting machine learning for end-to-end drug discovery and development. Drug Discovery Today, 12(13–14), 604–610.
- Shankar, S., & Schreiber, S. L. (2015). Network pharmacology: a new paradigm for drug discovery. Trends in Pharmacological Sciences, 36(10), 695–705.
- Sun, J., Zhang, J., Zhu, Y., & Yu, H. (2013). Computational prediction of drug–target interactions using a network-based approach. PLoS ONE, 8(12), e81732.
- Smith, R. D., Koehler, J., & Denny, J. C. (2012). Integrating artificial intelligence in drug discovery: from computational models to clinical trials. Drug Discovery Today, 17(5–6), 240–247.
- Rai, A., Masoodi, T., & Saini, R. (2018). Deep learning approaches for drug repurposing. Briefings in Bioinformatics, 20(5), 1560–1570.
- Mijit, M., Bell, D., & Hsiao, C. (2015). Artificial intelligence approaches in rare diseases: a review. Journal of Rare Disorders, 3(2), 98–110.
- Zhang, W., Li, H., & Chen, L. (2017). Machine learning in drug repurposing: applications and opportunities. Journal of Medicinal Chemistry, 60(2), 602–610.
- Zhou, Y., Hou, Y., Shen, J., Huang, Y., Martin, W., & Cheng, F. (2018). In silico screening and drug repurposing: a network pharmacology perspective. Journal of Chemical Information and Modeling, 58(4), 712–719.
- Gupta, A., Kumar, V., & Singh, P. (2012). Leveraging machine learning for repurposing anticancer drugs. Journal of Bioinformatics and Computational Biology, 10(4), 789–804.